The Research Center at Cihan University Duhok held an international workshop on Google Meet platform entitled “Learning from gut instinct” It is about gut health and Microbiota and how it is related to health outcomes.
🎙️ Key speaker:
📌 Dr. Jumana Samara, Neonatology Specialist HMO at a section of neonatology, HSC, Winnipeg, Manitoba, Canada.
🎙️ Session management:
📌 Dr. Mervan Yousif Huseyin , a lecturer in department of medical laboratory at our university.
Workshop summary is about:
Probiotics are increasingly administered to premature infants to prevent necrotizing enterocolitis and neonatal sepsis. However, their effects on gut microbiome assembly and immunity are poorly understood. Using a randomized intervention trial in extremely premature infants, we tested the effects of a probiotic product containing four strains of Bifidobacterium species autochthonous to the infant’s gut and one Lacticaseibacillus strain on the compositional and functional trajectory of the microbiome. Daily administration of the mixture accelerated the transition into a mature, term-like microbiome with higher stability and species interconnectivity. Besides infant age, Bifidobacterium strains and stool metabolites were the best predictors of microbiome maturation, and structural equation modeling confirmed probiotics as a major determinant for the trajectory of microbiome assembly. Bifidobacterium-driven microbiome maturation was also linked to an anti-inflammatory intestinal immune milieu. This demonstrates that Bifidobacterium strains are ecosystem engineers that lead to an acceleration of microbiome maturation and immunological consequences in extremely premature infants.
For more details, please download this PDF: Cell&Host PDF
